Most portable optical mice aimed at laptop users tend to be so tiny as to be uncomfortable for anything other than occasional use. Although it's still a bit small for anyone with large hands, the Ergo 300, available in metallic red or silver, is more comfortable than most. It has a slight hump, which helps the mouse feel more snug, although it's suitable only for right-handed people.
There are two main buttons and a clickable scroll wheel, which can scroll horizontally as well as vertically.
The Ergo 300's comfort and small size make it a great choice if you can't stand using a track pad.